Taylor Airport fencing slated for completion

first_img By Toni Gibbons       During the Dec. 6 meeting of the Taylor Town Council, Town Manager Gus Lundberg presented the council with an airport task order saying, “This is for the design work which willSubscribe or log in to read the rest of this content. Bottom Ad December 10, 2018 Taylor Airport fencing slated for completionlast_img

Arizona Outrage over killing of black teen over rap music complaint

first_img Post Comment(s) By AP |Phoenix | Published: July 10, 2019 12:46:49 pm Amid video & bhog, Haryana village mourns six-year-old girl who died in Arizona desert Indian migrant girl died in Arizona desert as mother sought water The Maricopa County Attorney’s Office said it filed a direct complaint Tuesday charging Michael Adams, 27, in the Thursday morning killing. First-degree murder carries a sentence of life behind bars or death.Adams is next scheduled to appear in court on July 15. The Twitter hashtag (hash)JusticeForElijah began trending over the Independence Day weekend after police in the suburban Phoenix city of Peoria arrested Adams. He had been released from state prison two days before.“Another one of our children has been murdered in a heinous and unprovoked way_the DOJ must investigate this hate crime immediately,” Democratic candidate Cory Booker wrote on his Twitter account Monday. “RIP Elijah. (hash)JusticeForElijah.”Linda Sarsour, a Palestinian American civil rights activist from Brooklyn, New York, called the crime “outrageous” and said it recalled the 2012 killing of 17-year-old high school student Jordan Davis in Jacksonville, Florida. “Rest in power Elijah Al-Amin,” she wrote. Advertising Advertising Advertising More Explained Best Of Express Family members have told local media that Elijah Al-Amin would have turned 18 in two weeks and was looking forward to his last year in high school.Friends and family hugged Monday at the Islamic Community Center in Tempe, where prayers for the teen were held before burial in Maricopa County.A modest makeshift memorial outside the convenience store where Al-Amin was stabbed was still erected on Tuesday, with a pair of white porcelain angels, fresh flowers and burning calendars including one dedicated to the Virgin of Guadalupe, the Catholic patron saint of Mexico. There is no hate crime statute in Arizona, but a judge’s determination that a hate crime has occurred can toughen sentencing. Karnataka: SC to rule today, says Speaker’s powers need relook In undecided Congress, first open call for Priyanka: She should be party chief Two stranded Indian nationals apprehended for trying to enter US illegally NRC deadline approaching, families stranded in Assam floods stay home Explained: Kulbhushan Jadhav case file Cotterell said during the videotaped court hearing that “this is a failing on the part of the (Arizona) Department of Corrections.”Adam’s bond was maintained at $1 million. He had been freed July 2 after serving a 13-month sentence for aggravated assault. Department of Corrections spokesman Bill Lamoreaux said in a statement that “the tragic death is terrible, and Mr. Adams will have to answer for his alleged actions.”The statement said that when Adams was released he “was not designated seriously mentally ill” and that once the department transported him from the state prison complex in Yuma where he had served his sentence to Maricopa County it “had no further legal authority over him.”Many of the people commenting on Twitter said that claims about Adams’ mental illness should not be used to explain away what they believe was a hate crime. Related News Michael Dunn, who is white, was later convicted of first-degree murder in that earlier killing, a shooting that erupted during an argument about loud music coming from a car carrying Davis and other black teenagers.In the Arizona attack, first responders discovered Al-Amin collapsed outside the Peoria Circle K store’s gas pumps and took him to a hospital, where he died. Several people inside the store had watched as Al-Amin was stabbed in the throat and the back before he ran outside.Officers found Adams nearby with a pocket knife and blood on his body. Adams told them he had felt threatened by the rap music coming from Al-Amin’s vehicle.Adams’ attorney, Jacie Cotterell, told the judge at his initial appearance hearing that her client was mentally ill and released without any medication, “no holdover meds, no way to care for himself.” Adams was charged Tuesday, July 9, 2019, with first-degree murder. (AP)Hundreds of people including a presidential candidate spoke out on Twitter this week after a 17-year-old black youth was killed at a suburban convenience store, allegedly by a white man charged Tuesday with first-degree murder who has said he felt threatened by the boy’s rap music.last_img read more

New AUC published for lumbar puncture and spinal fluid analysis in Alzheimers

first_imgReviewed by James Ives, M.Psych. (Editor)Oct 10 2018In preparation for more tools that detect and measure the biology associated with Alzheimer’s and other dementias earlier and with more accuracy, an Alzheimer’s Association-led Workgroup has published appropriate use criteria (AUC) for lumbar puncture (spinal tap) and spinal fluid analysis in the diagnosis of Alzheimer’s disease.The AUC is available online by Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association as an article in press, corrected proof.”Early and accurate diagnosis of Alzheimer’s disease is critical as therapies that have the potential to stop or slow the progression of the disease become available,” said Maria C. Carrillo, Ph.D., Chief Science Officer at the Alzheimer’s Association. “These criteria will arm medical professionals with necessary guidance when the use of lumbar puncture is an appropriate part of the process to diagnose Alzheimer’s disease and other dementias, thereby giving people with dementia and their families the possibility of a head start in preparing for the course of their disease.”Alzheimer’s disease is commonly diagnosed by a thorough examination of physical health, medical history and assessment of memory, thinking and reasoning. Lumbar puncture, while not currently in routine clinical practice in the U.S., is anticipated to be a safe and cost-effective way to retrieve cerebrospinal fluid (CSF) to test for biological markers of Alzheimer’s disease, potentially delivering valuable diagnostic information to clinicians and their patients earlier in the course of the disease.The Workgroup’s efforts complement the 2013 AUC for brain amyloid PET scans developed by the Society of Nuclear Medicine and Molecular Imaging (SNMMI) and the Alzheimer’s Association.The lumbar puncture AUC criteria recommend clinicians consider the following patient populations as appropriate and inappropriate:Appropriate uses of lumbar puncture: Source:https://www.alz.org/ A patient is cognitively unimpaired, is within the normal range of functioning for their age and lacks significant risk factors for Alzheimer’s disease. A patient is cognitively unimpaired but is considered to be at risk for Alzheimer’s disease based on their family history. A patient has SCD and has been evaluated and found by a clinician not to be at high risk for Alzheimer’s disease based on indications such as no family history or limited concern from an informant like a partner or family member. A patient has symptoms of rapid eye movement (REM) sleep behavior disorder, which is a strong predictor of disorders such as Parkinson’s disease and Lewy body dementia. A patient already has been diagnosed with Alzheimer’s and the test’s use would be to determine the stage of their disease or its severity. A patient is an apolipoprotein E-e4 (ApoE-e4) carrier who has no cognitive impairment. ApoE-e4 is a genetic mutation strongly associated with risk for late-onset Alzheimer’s. The test is being used in lieu of genotyping for individuals who are suspected to carry a rare genetic mutation that causes an early-onset form of Alzheimer’s disease. The AUC includes suggestions from the workgroup on implementing the criteria in clinical practice. They recommend that CSF biomarker testing be done by dementia experts who can determine the appropriateness of the test, educate the patient and family about the benefits and risks, ensure the procedure follows established guidelines, and integrate the results into the patient’s treatment plan.center_img Related StoriesHealthy lifestyle lowers dementia risk despite genetic predispositionAn active brain and body associated with reduced risk of dementiaNew study identifies eight genetic variants associated with anorexia nervosaInappropriate uses of lumbar puncture: A patient has subjective cognitive decline (SCD) and is considered to be at an increased risk for Alzheimer’s disease based on indicators that include a persistent decline in memory, younger onset age (>60), onset in the last 5 years and others. The decision to perform CSF biomarker testing in this case should be individualized and most strongly supported when the individual, family and clinician all are concerned about the patient’s cognitive decline. A patient has mild cognitive impairment (MCI) that is persistent, progressive and unexplained. MCI includes mild deficits on cognitive testing but no change in functional abilities. A patient has symptoms that suggest possible Alzheimer’s disease, meaning the dementia could be due to another cause. A patient has MCI or dementia with onset at an early age (<65). A patient meets core clinical criteria for probable Alzheimer's disease with typical age of onset. A patient's dominant symptom is an unexplained change in behavior, such as delusions and delirium, and an Alzheimer's disease diagnosis is being considered.last_img read more

Study suggests new strategy to kill melanoma cells

first_imgReviewed by James Ives, M.Psych. (Editor)Oct 24 2018Think of the protein BH3 like a finger that turns off a cancer cell survival switch. The problem is that most cancer cells have found ways to remove this “finger” – commonly, by breaking the action of a gene called p53 that puts the BH3 finger in motion. Now think of Bcl-2 as the switch itself. When cancer breaks p53, the BH3 finger never moves, and the Bcl-2 survival switch remains on. Despite thousands of published studies, researchers haven’t had much luck directly protecting the action of p53. But, BH3 is another story. Drugs exist that mimic the action of BH3, collectively called (creatively…) “BH3 mimetics.” For example, the drug venetoclax is a BH3 mimetic that has earned FDA approval against the blood cancer CLL and shows promise against the related blood cancer, ALL.BH3 mimetics have also succeeded in the laboratory against the dangerous form of skin cancer, melanoma. But unlike blood cancers, it seems that melanoma has a sneaky way to work around BH3 mimetics.Now, a University of Colorado Cancer Center, Department of Dermatology, study published in the journal Cell Death and Disease shows how melanoma escapes existing BH3 mimetics, and suggests a new strategy to block this avenue of escape.The problem is that Bcl-2 itself is not the only switch that, when left in the “on” position, keeps cancer cells alive. BCL-2 describes a family of proteins, and even when Bcl-2 itself is turned off, melanoma cells can get equally effective survival signals from another member of the BCL-2 family, namely the protein MCL-1. The current study wondered what would happen if both these switches were turned off at the same time.When the group used a cousin of venetoclax, called navitoclax, to silence Bcl-2 along with the investigational drug A-1210477 to silence MCL-1, melanoma cells died. Not only did the combination of navitoclax and A-1210477 kill melanoma cells and melanoma patient samples regardless of the specific mutations driving the disease or whether the patient had received previous treatments, but the combination also killed the melanoma-initiating cells (aka cancer stem cells) that often resist treatment to restart the disease.Related StoriesBU researchers identify biomarker and possible new therapy for melanomaResearchers uncover cellular resistance mechanisms to BRAF inhibitors in melanomaPhysicians trained in dermatoscopy can improve odds for early detection of melanoma”In cancer cells, there is a mix of pro-death and anti-death proteins. Depending on the balance, these cells live or die. By using navitoclax and A-1210477 to mute Bcl-2 and MCL-1, we remove anti-death proteins and, on balance, cancer cells die,” says first author, Nabanita Mukherjee, PhD, faculty research associate in the CU School of Medicine Department of Dermatology. The work is published from the laboratories of Drs. David Norris and Yiqun Shellman.In addition to Bcl-2 and MCL-1, there was a third genetic player in this story of the BCL-2 family “survival switch.” In breast cancer, DRP-1 makes death proteins. But, the current study shows that in melanoma, DRP-1 has the opposite effect, making anti-death proteins. The combination of navitoclax and A-1210477 acted against DRP-1. In addition, when the group used CRISPR/Cas9 to completely mute DRP-1, melanoma cells were killed even more efficiently.”This finding has not been reported before, and our results suggest that DRP-1 inhibition would cooperate with BH3 mimetics therapy in melanoma,” Mukherjee says.”Although the treatments for melanoma have advanced dramatically, alternative options are still needed, especially for the patients who do not respond to or relapse from current targeted or immunotherapies,” says Mukherjee. “Our studies suggest that the concept of targeting multiple BCL-2 family members is worth exploring further for these patients.”Source: http://www.ucdenver.edu/last_img read more

Study highlights a new predictor of type 2 diabetes

first_img Source:https://www.henryford.com/news/2018/11/ultrasound-diabetes-study Reviewed by James Ives, M.Psych. (Editor)Nov 20 2018Henry Ford Hospital researchers may have unknowingly happened on a new predictor of type 2 diabetes as part of a new ultrasound shoulder study.The predictor may be an ultrasound of the deltoid muscle, which researchers found appears much brighter on diabetic patients than on obese nondiabetic patients. Researchers theorize the brighter appearance is due to low levels of glycogen in the muscle caused by patients’ insulin resistance.The study is being presented at the annual meeting of the Radiological Society of North America Nov. 25 – 30 in Chicago.Imaging the deltoid muscle by ultrasound may be an “opportunistic tool” for predicting prediabetes and diabetes and diagnosing patients who may be unaware they have the disease, says Steven Soliman, D.O., a Henry Ford musculoskeletal radiologist and the study’s lead author.”Our study shows that diabetic patients are having changes within their deltoid muscles, demonstrated by a bright appearance on ultrasound, indicating that maybe earlier treatment is warranted,” Dr. Soliman says. “And patients who may be undiagnosed and missed, such as prediabetics or diabetics who haven’t been diagnosed yet, may be able to be diagnosed earlier.”The study is believed to be the first in the United States to demonstrate a link between type 2 diabetes and this bright appearance of the deltoid muscle in diabetic patients.Researchers found that this bright appearance had an 89 percent predictive value of “definite diabetes.” For prediabetes patients, the bright appearance was a predictor of either “definite diabetes” or “suspected diabetes.”Diabetes is the seventh leading cause of death in the United States, according to the American Diabetes Association. In 2015, of the more than 30 million Americans who had diabetes, more than 7 million people were undiagnosed. In 2017, diabetes accounted for $237 billion in direct medical costs.Related StoriesUTHealth researchers investigate how to reduce stress-driven alcohol useDiabetes patients experiencing empathy from PCPs have beneficial long-term clinical outcomesIntermittent fasting may protect against type 2 diabetesThe use of musculoskeletal ultrasound, especially shoulder ultrasound, has increased sharply in the past 20 years across the country. At Henry Ford, diabetic patients typically undergo shoulder ultrasound because they are more prone to rotator cuff injuries.The Henry Ford study was borne from an emerging trend observed for at least 10 years by Dr. Soliman and his musculoskeletal radiology colleagues. They found that the number of ultrasound scans with the brighter, or hyperechoic, appearance of the deltoid muscle in diabetics was “out of proportion” to those seen in obese nondiabetic patients, even though the hyperechoic appearance is commonly seen in obese patients.In healthy patients, the deltoid muscle appears darker on the ultrasound when compared to the underlying rotator cuff tendon. For diabetic patients, the gradient is just the opposite, Dr. Soliman says.For their retrospective study, researchers sought to evaluate whether the bright appearance of the deltoid muscle was associated with diabetes or obesity. Of the 186 patients involved, 137 had type 2 diabetes and 49 were obese and nondiabetic.Researchers evaluated the results by assigning one of three diagnoses: definite diabetes, suspected diabetes or normal.Dr. Soliman says the findings have immediate implications for clinicians.”We believe you could use shoulder ultrasound as a supplemental screening option to evaluate for the appearance of a hyperechoic deltoid muscle,” Dr. Soliman says. “This could be used to evaluate for the multitude of patients who do not know they have diabetes.”last_img read more

New approach identifies epigenetic changes in leukemia cells for patients undergoing ibrutinib

first_imgReviewed by James Ives, M.Psych. (Editor)Jan 29 2019Many new anti-cancer drugs inhibit proteins that are essential for the proliferation of cancer cells. One example is ibrutinib, an innovative therapy for chronic lymphocytic leukemia first approved in 2014. Chronic lymphocytic leukemia is caused by uncontrolled growth of cells from the body’s immune system. It is the most common leukemia in the Western world.Ibrutinib breaks the circle of rampant cell proliferation and allows even patients with high-risk chronic lymphocytic leukemia to survive for many years. However, patients must keep taking the drug every day and endure side effects, often severe, including fever, pain, and fatigue.To improve the treatment of chronic lymphocytic leukemia toward higher efficacy and fewer side effects, scientists are increasingly exploring combination therapies. Ideally, such drug combinations exploit vulnerabilities that ibrutinib induces in leukemia cells, with the ultimate goal of hitting the leukemia in a hard enough way to later make treatment unnecessary.To speed up the search for promising drug combinations, a team of scientists at CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and the Medical University of Vienna developed a method that can effectively sift through a large number of possibilities and identify those drug combinations that have true potential. The work describing the outcome was published in Nature Chemical Biology (DOI: 10.1038/s41589-018-0205-2) on 28 January 2019.The new approach combines epigenetic analysis using a method called ATAC-seq (pronounced “attack-sec”) with comprehensive testing of single-cell drug sensitivity. This approach identified characteristic epigenetic changes in leukemia cells for patients undergoing ibrutinib treatment. On top, scientists performed high-throughput imaging, by automated confocal microscopy, to identify drug sensitivities that were specific for these leukemia cells and not for healthy cells of the very same patient. All of these experiments were done on primary samples collected from patients before and during ibrutinib treatment, which enabled a systematic analysis of ibrutinib-induced drug vulnerabilities.Related StoriesResearch reveals genomic basis of acute erythroid leukemiaOnline atlas created to identify, classify protein signatures present at AML diagnosisCancer stem cells elude the body’s immune cells by deactivating danger detectorChristoph Bock, Principal Investigator at CeMM and corresponding author of the paper emphasizes the relevance for personalized medicine: “To keep a cancer at bay, it often takes several drugs at the same time. The search for such combination therapies unfortunately involves a lot of trial and error. This is why we have developed a method that predicts and prioritizes what is likely going to work. The first results in chronic lymphocytic leukemia are promising, and I am convinced that our method will help develop personalized therapies for leukemia and other cancers.”Ulrich Jaeger, Professor of Hematology at the Medical University of Vienna and Head of the Clinical Department for Hematology and Haemostaseology at the Vienna General Hospital highlights the medical context of the new method: “Treatment of leukemias with single drugs carries the risk of resistance and failure to respond. A new method to develop combination therapies more systematically indeed constitutes an important advance for cancer research.”Giulio Superti-Furga, Scientific Director at CeMM and Professor for Medical Systems Biology at the Medical University of Vienna concludes: “The study is a beautiful example for translational medicine and the impact of basic research on clinical praxis. In summary, it provides a powerful method for the rational development of combination therapies and a step toward truly personalized oncology.” Source:https://cemm.at/last_img read more

Research could potentially lead to new treatments for neurodegenerative diseases

first_imgReviewed by James Ives, M.Psych. (Editor)Feb 1 2019Scientists from the University of Sheffield have identified new messenger molecules shuttled between cells which could help to protect the survival of neurones – potentially leading to new treatments for MND .The pioneering research has discovered the role of a small molecule which can regulate large signaling cascades and significantly improve the survival of neurones – something which will help pave the way to identify and develop new therapies for neurodegenerative diseases.MND, also known as Amyotrophic Lateral Sclerosis (ALS), is a devastating neurogenerative disorder that affects the nerves – motor neurones – in the brain and spinal cord that tell your muscles what to do. The messages from these nerves gradually stop reaching the muscles, leading them to weaken, stiffen and eventually waste. The progressive disease affects a patient’s ability to walk, talk, eat and breathe. MND affects 5,000 adults in the UK and there is currently no cure.Related StoriesNanoparticles used to deliver CRISPR gene editing tools into the cellWearing a hearing aid may mitigate dementia riskResearch sheds light on sun-induced DNA damage and repairApproximately 10 per cent of MND cases are inherited but the remaining 90 per cent of MND cases are caused by complex genetic and environmental interactions which are currently not well understood – this is known as sporadic MND. The most common known genetic cause of MND is a mutation of the C9orf72 gene.Although MND affects the survival of neurones, other supporting cell types such as astrocytes – star-shaped glial cells in the brain and spinal cord – play an important role in the progression of the disease. Normally responsible for keeping the neurones protected and nourished, astrocytes can become toxic in MND. In a healthy organism, these cells release pockets of vesicles containing messages to communicate with other cells. In MND, these extracellular vesicles (EVs) can contain toxic factors – no longer supporting the neurones but instead contributing to their death.The new research, led by Dr Laura Ferraiuolo from the University of Sheffield’s Insitute of Translational Neuroscience (SITraN) found that when the micro-RNA molecule – which can regulate large signaling cascades – is introduced to an astrocyte-motor neurone culture, the survival of neurones was significantly improved.The micro-RNA identified in the study, called miR-494-3p, regulates genes involved in maintaining the health and strength of neurones axons. Researchers also found miR-494-3p was significantly depleted in cells derived from patitents with sporadic MND.Dr Ferraiuolo from SITraN and lead author of the study said: “When an artificial form of miR-494-3 was introduced to the astrocyte-motor neuron culture, the survival of neurons was significantly improved.”The study shows that restoring depleted micro-RNAs can improve cell survival. The results not only shed more light on the mechanisms of this complex disease, but they hold massive potential for the identification and development of new therapies for ALS and other neurodegenerative diseases.” Source:https://www.sheffield.ac.uk/last_img read more

MedTech Innovation Expo 2019 Offers Insight Debate and Pioneering Technology

first_imgThere is a lot to be gained from attending any one of the three conference stages. You’ll find world-class experts offering insights on everything from implantable devices, the impact of Brexit on the MedTech industry and digital start-ups to women in medical plastics, the recycling of medical devices and efficient design for patients and organizations.Dave Gray, the Group Editor at Med-Tech Innovation News By Lois Zoppi, BAApr 8 2019The Med-Tech Innovation Expo 2019 brings together the most exciting speakers, products, and innovations in medical technology, medical plastics, digital devices, and pharmaceuticals. With 200 exhibitors, the Med-Tech Innovation Expo gives attendees an invaluable chance to meet designers, engineers, manufacturers, and innovators from the medical and healthcare industries.Taking place at the NEC Birmingham, UK, the Med-Tech Innovation Expo 2019 runs from 15th to 16th of May. There are several new additions to the Med-Tech Innovation Expo 2019, including:The Med-Tech Innovation ConferenceThe Med-Tech Innovation Conference, in association with Medilink UK, will offer presentations from Boston Scientific, Roche Diagnostics, and NHS England, among others.A “world-class” learning programme will feature champions of the medical field over two days, with speakers ranging from blue-chip users, government officials, and industry experts.The Med-Tech Introducing stageThe Med-Tech Introducing stage allows exhibitors to showcase their latest innovations, news, materials, and more in a series of quick-fire presentations. Companies can even launch at the Med-Tech Introducing stage, making this a fascinating insight into the newest talent in the medical sectors. MD-Tech, Bemis Healthcare Packaging, and Datalink Electronics are just some of the speakers already confirmed for this event.Highlights include “How 3D printed conductive inks are being used to improve medical device design” with speaker Gethin Roberts from Iterate Design. Iterate is dedicated to the development of new products, and they have created a new 3D printing technology, which has successfully been used to design sensor-controlled prosthetics. Prosthetics made with Iterate’s latest printing technology are more adaptable, lightweight, and cost-effective, bringing significant benefits to users.Arash Gadar from Datalink Electronics tackles the issues raised by connected healthcare platforms from security and data management to remote monitoring, and the use of artificial intelligence. New advances in connected healthcare systems will also be explored in the talk titled “Towards a Ubiquitous Connected Healthcare System.”The HealthTech StageHaving debuted in 2018 to great success, the HealthTech Stage will run again in 2019. Innovate UK and the National Institute for Health Research (NIHR) are set to present at this year’s Med-Tech Innovation Expo. Visitors to the HealthTech Stage are able to meet innovators and explore new technology during a program offering up to date news on hardware, software, materials, and services.Speakers include Steve Cox, 3D Tech Consultant with AMFORI Consulting. In his talk, “Disrupting Disability with 3D Technologies”, Cox will cover how emerging 3D design and fabrication technology is influencing the disability sector. Generative Design, a new design technique for creating optimized designs has recently been applied to a wheelchair and will be discussed during the twenty-minute talk; exploring how this fresh design approach will advance wheelchair designs to be more easily customizable in the future.Additionally, Michael Kipping of Innovate UK will be heading a talk “Investment Opportunities for Startups”. Kipping will offer advice on funding opportunities for UK SMEs to help new companies develop new products and tackle the challenges they may face before getting their new products to markets.Showcasing Metrology and Inspection TechnologyMed-Tech Innovation Expo’s brand Inspex will highlight the challenges faced in metrology and inspection in healthcare. Companies providing metrology and inspection hardware, software, or services will be highlighted on the show floor, as well as in show guides and online exhibitor lists, and visitors will be able to meet with representatives from measurement, inspection, and testing technology business that are leaders in their fields.SummaryMed-Tech Innovation Expo offers a wide range of new events to showcase the best innovations, products, and services in the Medtech sector. Visitors can gain a unique insight into industry and research and development through two full programmes of debate and discussion, and a broad number of the country’s leading companies will be in attendance bringing engaging content across MedTech, medical plastics, digital devices, and pharmaceutical technology. Sergey Nivens/ShutterstockNew Stage Events for Med-Tech Expo 2019 Source: https://med-techexpo.com/medtechinnovationexpo2019/en/page/why-visitlast_img read more

Innovative magnetic nanoparticles show potential for PETMRI bimodal imaging applications

first_imgMay 15 2019In a paper published in the American Chemical Society journal researchers from Bourgogne University showed that the use of superparamagnetic iron oxide nanoparticles (NPs) using multi modal – PET/MRI – showed promising improvements in imaging capabilities. The combination of simultaneous MRI/PET imaging is very attractive because it allies the high resolution of MRI with the high sensitivity of PET to obtain accurate anatomical and quantitative information at the same time.” Using an MR Solutions, cryogen free, 3T scanner with a PET clip on the sequential images were found to be highly beneficial providing high spatial resolution, high sensitivity, high technical maturity with a low radiation dose.Professor Nadine Millot Principal Investigator on the Study commented:center_img Related StoriesMR Solutions reveals elegant bench top CT scanner with clip-on PET and SPECTMR Solutions’ 7T MRI imaging system installed at University of HawaiiMR Solutions to showcase latest multi-modality MRI systems at EMIM 2019This pioneering agent highlights activity in the liver, spleen, lungs and kidneys before being gradually excreted from the body with no cytotoxicity observed.This is the first successful grafting of PEG and MANOTA chelator on prefunctionalized iron oxide NPs synthesized under continuous hydrothermal conditions for bimodal PET/MRI imaging and shows the potential benefits.MR Solutions remains the only company with commercial installations of cryogen free MRI scanners – from 3T to 7T. All of these scanners can be fitted with either clip-on PET scanners for sequential scanning or inserted into the bore to provide simultaneous scanning.The same PET clip-ons can also be used on the recently launched range of MR’s CT scanners.Source:MR SolutionsJournal reference:Millot, N. et al. (2019) Innovative Magnetic Nanoparticles for PET/MRI Bimodal Imaging. ACS Omega. doi.org/10.1021/acsomega.8b03283last_img read more

New strategy may strengthen gutbrain communication

first_imgThe development of this model system also will allow researchers to begin investigating the complex interactions of the microbiome and diet with enteroendocrine cell function.Since several of the hormones and effector molecules released by enteroendocrine cells are already targets for the treatment of diseases such as type 2 diabetes and irritable bowel syndrome, we expect this model to aid in identifying novel therapeutics to treat these and other human diseases.”Prof. Dr. Robert Britton By Angela Betsaida B. Laguipo, BSNJun 28 2019The communication system between the gut and brain is known as the gut-brain axis and is well established. Now, scientists have developed a strategy that raises the volume of gut-body communication, paving the way for new interventions to improve human health.Lightspring | ShutterstockResearchers at the Alkek Center for Metagenomics and Microbiome Research and the Dan L Duncan Comprehensive Cancer Center at Baylor College of Medicine aimed to study enteroendocrine cells, which are hormone-producing cells in the gastrointestinal tract. These cells are dubbed as vital moderators in the communication between the gut and other parts of the body.Specialized hormone-producing cellsTo land to their findings, the researchers partnered with scientists at the Baylor and Texas Children’s Hospital to formulate a new strategy that an increase in the number of specialized cells.”Enteroendocrine cells are extremely challenging to study because we just don’t have a lot of cells,” Dr. Joseph M. Hyser, assistant professor of virology and microbiology and member of the Alkek Center for Metagenomics and Microbiome Research, said in a statement.”They represent less than 1 percent of all the cells in the intestinal epithelium,” he added.Enteroendocrine cells are usually found in the wall of the gut. They produce and secrete a hormone that helps maintain numerous body processes, such as controlling food intake, blood glucose levels, and stomach emptying.They are found in the pancreas, stomach, and gastrointestinal tract. The hormones may be released into the bloodstream to trigger systemic effects and nervous response.Increasing communicationEnteroendocrine cells (EECs) are specialized epithelial cells responsible for producing molecules that are important for intestinal balance. However, they are limited in number, making it hard for researchers to study them.To study the cells, the researchers from Hyser and Chang-Graham partnered with other scientists at Baylor and Texas Children’s Hospital to create a technique that can help increase the number of Enteroendocrine cells.The researchers used a type of human intestinal epithelial cell culture system dubbed as enteroids. To increase the number of the cells, they used previous work on the overexpression of the transcription factor neurogenin-3 drives stem cells in the gut to grow as enteroendocrine cells. Simply put, they used genetically-engineered human intestinal enteroids to express the gene neurogenin-3, which can be induced by doxycycline, creating a molecular switch.Doxycycline, when added to the cultures, boosted the production of neurogenin 3, triggering the expression of other genes and the development of endocrine enteroid cells. As a result, the number of endocrine enteroid cell production increased from 1 to 40 percent.Furthermore, the endocrine enteroid cell population, which were expanded, were able to respond to viral and hormonal stimuli as native endocrine cells in the gastrointestinal tract do. They were able to secrete serotonin and other neurotransmitter mediators. Also, their levels increased and became easily detectable.Promising resultsWith the results of the new study, the researchers can now create more endocrine cells, which can be seen and examined under the microscope. The researches can now also study and measure physiological responses.The technique helped develop a system that can help study how the gut communicates with the body through whispered messages. In turn, the system has been used to increase or raise the volume of the chemical whispered messages. Hence, it helps the researches become aware of how the gut interacts with the rest of the body.It can also help facilitate the research on how the gut affects health and provide a means to formulate and test new interventions to treat various diseases. For instance, researchers can use the technique to analyze how viruses like rotavirus regulate the responses of the endocrine guy populations. Journal reference:Chang-Graham, A., Danhof, H., Engevik, M., Tomaro-Duchesneau, C., Karandikar, U., Estes, M., Versalovic, J., Britton, R. and Hyser, J. (2019). Human Intestinal Enteroids With Inducible Neurogenin-3 Expression as a Novel Model of Gut Hormone Secretion. CMGH Journal.last_img read more

Israel bourse bullish on blockchain cagey on crypto

An Israeli consultant trades the cryptocurrency, bitcoin, online, in the Israeli city of Tel Aviv in this picture taken on January 17, 2018 This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Kodak surges at it becomes latest ‘cryptocurrency’ convert Ittai Ben Zeev told journalists it was crucial to differentiate between cryptocurrencies, like bitcoin, and the basic technology which enables them.”We are only talking about the technology itself,” he said in English. “You have to separate between blockchain and crypto.”Blockchain technology allows the development of peer-to-peer payment systems.It runs by recording transactions as “blocks” that are updated in real time on a digitised ledger that can be read from anywhere and does not have a central record keeper.Ben Zeev said TASE was close to announcing a project using blockchain for the first time but he refused to elaborate.”Hopefully next week we can come out with it,” he said. “I guarantee it will be interesting.”In March 2017 TASE and Intel co-hosted a two-day blockchain hackathon in Tel Aviv, brainstorming possible applications and ventures.”It was a very successful hackathon and since then we’ve been thinking of ways to get an advantage from blockchain technology,” Ben Zeev said. “All the financial institutions all over the world are thinking about it.””Blockchain is a fascinating technology with great potential.”Some people say it’s like the internet 25 years ago,” he added. “If that does prove true it will have a major impact on the industry.”He ruled out near-term TASE involvement in so-called Initial Coin Offerings (ICOs) where companies seek to raise funds through creating their own virtual currencies.”Bear in mind that we have 1,400 cryptocurrencies all over the world,” he said.”To me it’s still unclear what stands behind the logic of how to price cryptocurrency.”He said TASE would base its future decisions on what rules Israeli financial regulators and politicians adopt.”Until the government says what it thinks we are not going to be the pioneers,” he said. “We want to see what the guidelines are.” The Tel Aviv Stock Exchange (TASE) is bullish about the potential for blockchain technology but sees involvement in cryptocurrency trading as far away, its chief executive said on Monday. © 2018 AFP Citation: Israel bourse bullish on blockchain, cagey on crypto (2018, February 5) retrieved 18 July 2019 from https://phys.org/news/2018-02-israel-bourse-bullish-blockchain-cagey.html Explore further read more

Volunteers work to save vintage train simulator in Berlin

In this Friday, May 4, 2018 photo Tobias Hirsch of the ‘Historic City Train Driving Simulator’ poses in the simulator cockpit in Berlin, Germany. (AP Photo/Michael Sohn) In this Friday, May 4, 2018 photo the video system of the ‘Historic City Train Driving Simulator’ is pictured in Berlin, Germany. (AP Photo/Michael Sohn) Explore further Air is pressurized by an electric engine for the brake system. The cylinders move the train cab noisily forward and backward, left and right to mimic the movements of a real train on a track. And, it occasionally lets off an alarm.”This was a huge innovation back then in the 1960s,” said Tannigel, an energetic 54-year old who still works as a teacher for train drivers in Berlin. “That you could use a simulator to train drivers. That was very advanced.”East German train authorities commissioned the unit from their research and development unit in Halle after visiting a train simulator in Britain produced by General Precision Systems. A few hundred guests visit by appointment each year, and are allowed to test their skills driving the train through the Berlin of three decades ago, watching out for signals, stopping at stations, opening and closing the doors and informing their imaginary passengers of upcoming stations and possible delays.More advanced visitors—a large number of them are retired train drivers—are given the opportunity to encounter emergency scenarios such as a loss of brake pressure or electricity. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. In this Friday, May 4, 2018 photo Tobias Hirsch holds a Laser Video disk of the ‘Historic City Train Driving Simulator’ in Berlin, Germany. (AP Photo/Michael Sohn) After testing, it was put into use in 1969 for the training of locomotive drivers.Thousands of drivers were trained on the machine, which in those days used 16mm film on a screen. The cabin was set up like a diesel locomotive from the Deutsche Reichsbahn.In 1988, it was moved to Berlin and refitted to match the city’s local “S-Bahn” commuter train service. The simulator was kept in service after the fall of the Berlin Wall in 1989 and the following reunification of Germany, and it got its upgraded LaserDisc video system and Commodore computer over the next two years. More information: www.historischerfahrsimulatorberlin.de © 2018 The Associated Press. All rights reserved. In this Friday, May 4, 2018 photo Tobias Hirsch holds an electronic contol board of the ‘Historic City Train Driving Simulator’ in Berlin, Germany. (AP Photo/Michael Sohn) Tannigel and his fellow volunteers ask people to make donations, but there is no official charge to come and drive the simulator.But with frequent breakdowns of the Amiga computer and the LaserDisc player, Tannigel fears the time will soon come when he can’t operate the simulator any more.He’s been trying to raise 10,000 euros ($12,000) to add a new computer with modern software and to digitalize the historic videos for future playback. In addition to an advertising campaign to try and get more visitors to the museum, a crowdfunding page has also been started but it’s far away from the goal with only about 300 euros ($355) pledged so far. In this Friday, May 4, 2018 photo Tobias Hirsch poses at the hydraulic system of the ‘Historic City Train Driving Simulator’ in Berlin, Germany. (AP Photo/Michael Sohn) Tannigel gets help from two volunteers, both studying to become train drivers, who put in countless hours helping limp the simulator along by repairing broken parts and restarting the computer endlessly.”It is a lot of fun,” said 22-year-old Tobias Hirsch, one of the volunteers. “But at the same time, I also think it is really important to preserve this train history for the future.” Hydraulic systems jerk and pull the metal train cab back and forth as the driver pilots it along the tracks of Berlin’s commuter rail system, as images of the city just after the fall of the Berlin Wall whiz by. In this Friday, May 4, 2018 photo Tobias Hirsch of the ‘Historic City Train Driving Simulator’ poses in the simulator cockpit in Berlin, Germany. (AP Photo/Michael Sohn) Germany’s Flixbus takes on Deutsche Bahn with train routes It was finally taken out of service in 1996 in favor of a newer model and that might have been its end, but Tannigel took it upon himself to save the old simulator and established the museum where it’s housed today. In this Friday, May 4, 2018 photo Tobias Hirsch sits in the entrance of the ‘Historic City Train Driving Simulator’ in Berlin, Germany. (AP Photo/Michael Sohn) Citation: Volunteers work to save vintage train simulator in Berlin (2018, May 10) retrieved 18 July 2019 from https://phys.org/news/2018-05-volunteers-vintage-simulator-berlin.html Completed in communist East Germany in 1968, the one-of-a-kind train simulator had its last major overhaul nearly 30 years ago when it was outfitted with then-state of the art equipment—its 16mm film screen replaced with LaserDisc technology and a Commodore Amiga 3000 computer installed to run the system.Not surprisingly, those systems today are breaking down more and more frequently, and volunteers who have kept the unit running in a museum in an industrial building on the eastern outskirts of the German capital are now trying to raise the funds to save it.”It has quite a historical importance,” said Lutz Tannigel, the last teacher to use the simulator to test train drivers. “It was the first simulator that the Deutsche Reichsbahn (East German national railway) had. And we still have it and it still works, so it is absolutely imperative to maintain it for the future.”Built in the city of Halle, northwest of Leipzig, it was a sort of early virtual reality experience that was used to teach train drivers to deal with unexpected emergencies such as the loss of break pressure or an electrical fault. read more

VW sees steady profits in 2018 results

first_img Operating profit inched up 0.1 billion euros to 13.9 billion last year, the Wolfsburg-based group said in preliminary results, released unexpectedly ahead of its March 12 annual earnings press conference.Meanwhile the sprawling 12-brand conglomerate increased unit sales by 0.9 percent to 10.8 million vehicles, a new yearly record—powering annual revenues up 2.7 percent at 235.8 billion euros.Chief executive Herbert Diess hailed a “good showing in 2018, especially against the background of the switch to WLTP”, new emissions tests that proved a massive bottleneck for the whole industry from their introduction in September.VW was particularly happy to hit the high end of its profit margin target, at 7.3 percent—slightly down on 2017’s level.But the group said it also spent 3.2 billion euros—the same amount as the previous year—in one-off costs related to its 2015 admission to cheating on regulatory tests for 11 million diesel vehicles worldwide.VW’s preliminary results release came on the same day as a non-binding opinion from the Federal Court of Justice (BGH), Germany’s highest tribunal, on claims against the firm over manipulated vehicles.Senior judges leaned towards backing customers’ claims against Volkswagen, potentially pointing the way for future deliberations in lower courts over the 2.4 million such cars sold in Germany.Despite the legal risks and the costs of a massive push for new electric and hybrid models, the supervisory and executive boards proposed an increased dividend of 4.80 euros per share, up from 3.90 for 2017.Looking ahead to 2019, the group said it would “slightly exceed” last year’s unit sales figure despite challenges from a slowing economy, intensifying competition and volatile exchange rates.Revenues should increase by up to 5.0 percent year-on-year and operating profit between 6.5 and 7.5 percent, bosses forecast.Investors appeared unmoved by the positive results announcement, with VW shares shedding 0.64 percent to trade at 145.64 euros around 4:50 pm (1550 GMT) in Frankfurt. The cost of dieselgate is still a cloud over Volkswagen’s earnings Diesel fallout and trade headwinds sap Daimler in 2018 German car giant Volkswagen on Friday reported steady operating profit and rising revenues in 2018, but said its “dieselgate” emissions cheating scandal again inflicted one-off costs of 3.2 billion euros ($3.6 billion). Citation: VW sees steady profits in 2018 results (2019, February 22) retrieved 17 July 2019 from https://phys.org/news/2019-02-vw-steady-profits-results.htmlcenter_img © 2019 AFP Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Privacy poisoning poses threat to companies using blockchain

first_imgUnder GDPR, individual privacy rights include the “right to be forgotten,” which means that any personal data appearing publicly would have to be deleted.”Organizations that implement blockchain systems without managing privacy issues by design will run the risk of storing personal data that can’t be deleted without compromising chain integrity,” according to a Gartner report.Willemsen cited a story, which he admitted may be apocryphal, of a meeting by the European Commission where a participant paid for a pizza in bitcoin and the recipients thought it would be funny to immortalize the moment by putting their names in text fields that can be written into the bitcoin blockchain.”You would indeed always be remembered, and therein exactly lies the problem,” Willemsen said.These text fields in public blockchains are indelible. Willemsen noted that what constitutes personal information covers many things, from names to unique references that can be traced back to an individual.Willemsen said Gartner clients have had similar problems, though he declined to discuss the circumstances, citing confidentiality agreements.Indelible vs. erasableIn addition to the California law, similar legislation, with strong consumer privacy protections, is pending in New York, New Jersey and Washington.Businesses seeking to use blockchain as a secure solution may want to rethink, said Jenny Leung, a lawyer with Blakemore, Fallon, Garcia, Rosini & Russo in New York.She noted that on Jan. 1, 2020, the CCPA will give California consumers the “right to erasure” which is similar to the GDPR’s right to be forgotten, in that it allows people to request companies to delete any personal data they have stored. But information stored on a blockchain can’t be erased, which can get companies into trouble with the law if they’ve launched or organized the blockchain-based service, she said.The only way to delete the data may be through an elaborate “reforking” process, which moves the entire network to a new set of data and invalidates the old set.Private blockchains are slightly more resistant to privacy poisoning, although it can occur. In those cases, any companies that are still connected to the ledger can force all the participants to join in a “hard fork” to erase the offending data. Or private blockchains can force all them to stop operating or destroy all copies of private keys to render the encrypted data permanently inaccessible, Leung said.This process becomes too expensive and complicated for public blockchains, she said. It might take hundreds of millions of dollars to rent enough crypto-mining equipment to alter the network or orchestrate a hard fork by convincing the majority to move to a new chain that doesn’t contain the affected data.”It’s not something you want to do every time you want to delete something,” Leung said. “It’s costly and time-consuming.”Besides malicious attacks, Willemsen noted that many instances will most likely be caused by human error and bad process design. It doesn’t matter under the GDPR if a blockchain exposed personal data innocently through an error, he said.Once privacy poisoning becomes more widespread, Willemsen said he expects several things to happen. The first is that people will continue to disregard privacy practices the same way they do for other types of cybersecurity. Automated hacking tools may emerge from certain online communities to target exposed public blockchains or to render competitors’ systems useless, he said.Companies interested in using a public ledger may want to opt for private blockchains, said Randi Eitzman, senior threat pursuit analyst with FireEye iSIGHT Intelligence, a cybersecurity threat research and analysis service.Blockchains are ultimately “just costly centralized data storage,” Eitzman said in an emailed response to questions. “Firms looking for secure data storage might avoid using them depending on their cost-benefit analysis, but a simple solution would be to avoid storing any sensitive customer information on a blockchain.”Regarding attacks on public blockchains, Eitzman noted that easy-to-use tools that allow anyone to write and store data on-chain, such as Bitstagram, a mobile application that lets users upload their smartphone photos to a blockchain, already exist. With such tools, it wouldn’t take much for someone to upload illegal content, she said.”The benefit of a public ledger is that all transactions are easily viewable and can be tracked,” she said. “Anyone who stores sensitive or illegal content on-chain is doing so at their own risk.” Known as privacy “poisoning,” the attack involves loading private data, such as names, addresses and credit card numbers, or illegal material, such as child pornography, into a blockchain, therefore putting the network in conflict with local laws. The result is that the affected chain with all of its contained data cannot be used unless expensive and time-consuming steps are taken.Blockchain is a digital ledger of transactions run on a network of computers with no centralized governing or regulatory authority. It’s run by those who use it. The technology is increasingly being explored by banks and financial services firms, governments and startup businesses for its potential to improve the effectiveness of payment systems while cutting costs.A factor in the rise of blockchain poisoning is the introduction of strong data privacy laws such as the European Union’s General Data Protection Regulation, or GDPR, and California’s Consumer Privacy Act, or CCPA. Both allow consumers to request that personal data held by a company be deleted or erased.This is a problem for blockchain systems because they are designed to prevent changes to past transactions, and there is no central authority charged with correcting problems. So-called public blockchains such as those that underpin cryptocurrencies like bitcoin and ether are most at risk because anyone can participate. Participants in private blockchains must be invited and validated by the network starter.Bart Willemsen, an analyst with research firm Gartner Inc., said the one-two punch of privacy poisoning and privacy laws will hit public blockchains especially hard.Willemsen estimated that by 2022, three out of four public blockchains will suffer privacy poisoning—inserted personal data that renders the blockchain noncompliant with privacy laws. Businesses wanting to implement the technology must determine if any of the data being used falls under privacy laws, he said in an interview. Credit: CC0 Public Domain ©2019 CQ-Roll Call, Inc., All Rights Reserved Distributed by Tribune Content Agency, LLC. Explore further Protecting the ‘right to be forgotten’ in the age of blockchain Citation: Privacy ‘poisoning’ poses threat to companies using blockchain (2019, April 10) retrieved 17 July 2019 from https://phys.org/news/2019-04-privacy-poisoning-poses-threat-companies.html A new type of cyberattack that can render blockchain technology unusable may become a major headache for organizations that depend on it. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Passwords serve a personal purpose

first_img Citation: Passwords serve a personal purpose (2019, May 28) retrieved 17 July 2019 from https://phys.org/news/2019-05-passwords-personal-purpose.html Surveys conducted by Robbie Taylor, who is completing a Ph.D. in Psychology, alongside Professor Maryanne Garry from the University of Waikato, found around half of the respondents infused their passwords with autobiographical memories.”Many of the passwords our respondents told us about were facts—the old street name where they grew up or something else from their childhood,” says Robbie.”A lot of people also said they mix and match different facts, like a pet name and a year, or that they substitute some letters for numbers or symbols. They’re meaningful units disguised to create a potentially more secure password.”Around 10 percent of the survey respondents infused their passwords with episodic future thoughts, which are simulations of events that might happen in the future.”We found many passwords were associated with memories that served functions. For example, some people used their passwords to help them achieve goals, like saving for a holiday,” says Robbie.”These memories and passwords likely serve a directive function, by motivating and reminding people of what they want to achieve.”Robbie says there’s one obvious explanation for why people infuse their passwords with personal information—because the passwords are easier to remember.”People are trying to reduce the burden of remembering completely random passwords. People are potentially trading off security for ease of remembering.”The other explanation we found some evidence for is people might want to recall these memories when they type their passwords. That is, people might use passwords like digital mementos. Many people keep meaningful photos and physical mementos around their office at work. Some people may not look at these mementos to remind themselves of the associated memories very often. But, perhaps people with meaningful passwords might think of those associated memories more often because they type their password frequently. It could be a strategy to savour certain memories.”The study was inspired by a 2014 article in the New York Times.”The article described the dilemma some companies faced following the September 11 attacks, in which a large number of their employees died,” says Robbie.”One financial company needed to access the work files of the deceased, so they rang around asking family members for personal details to potentially find facts that could be in those passwords. The company found this method surprisingly successful.”It’s quite an interesting behaviour and, as we found, it’s quite common.” Bypassing popular passwords Explore further Credit: CC0 Public Domaincenter_img A Victoria University of Wellington study has shown that people build their passwords from personal information for a variety of reasons including to invoke important memories or achieve future goals. Provided by Victoria University of Wellington This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Storing data in music

first_imgManuel Eichelberger and Simon Tanner, two ETH doctoral students, store data in music. This means, for example, that background music can contain the access data for the local Wi-Fi network, and a mobile phone’s built-in microphone can receive this data. “That would be handy in a hotel room,” Tanner says, “since guests would get access to the hotel Wi-Fi without having to enter a password on their device.” To store the data, the two doctoral students and their colleague, Master’s student Gabriel Voirol, make minimal changes to the music. In contrast to other scientists’ attempts in recent years, the researchers state that their new approach allows higher data transfer rates with no audible effect on the music. “Our goal was to ensure that there was no impact on listening pleasure,” Eichelberger says.Tests the researchers have conducted show that in ideal conditions, their technique can transfer up to 400 bits per second without the average listener noticing the difference between the source music and the modified version (see also the audio sample). Given that under realistic conditions a degree of redundancy is necessary to guarantee transmission quality, the transfer rate will more likely be some 200 bits—or around 25 letters—per second. “In theory, it would be possible to transmit data much faster. But the higher the transfer rate, the sooner the data becomes perceptible as interfering sound, or data quality suffers,” Tanner adds.Dominant notes hide informationThe researchers from ETH Zurich’s Computer Engineering and Networks Laboratory use the dominant notes in a piece of music, overlaying each of them with two marginally deeper and two marginally higher notes that are quieter than the dominant note. They also make use of the harmonics (one or more octaves higher) of the strongest note, inserting slightly deeper and higher notes here, too. It is all these additional notes that carry the data. While a smartphone can receive and analyse this data via its built-in microphone, the human ear doesn’t perceive these additional notes.”When we hear a loud note, we don’t notice quieter notes with a slightly higher or lower frequency,” Eichelberger says. “That means we can use the dominant, loud notes in a piece of music to hide the acoustic data transfer.” It follows that the best music for this kind of data transfer has lots of dominant notes—pop songs, for instance. Quiet music is less suitable.To tell the decoder algorithm in the smartphone where it needs to look for data, the scientists use very high notes that the human ear can barely register: they replace the music in the frequency range 9.8-10 kHz with an acoustic data stream that carries the information on when and where across the rest of the music’s frequency spectrum to find the data being transmitted.From the loudspeaker to the micThe transmission principle behind this technique is fundamentally different from the well-known RDS system as used in car radios to transmit the radio station’s name and details of the music that is playing. “With RDS, the data is transmitted using FM radio waves. In other words, data is sent from the FM transmitter to the radio device,” Tanner explains. “What we’re doing is embedding the data in the music itself—transmitting data from the loudspeaker to the mic.” Provided by ETH Zurich Citation: Storing data in music (2019, July 9) retrieved 17 July 2019 from https://phys.org/news/2019-07-music.html A new technique allows data to be sent via music from a loudspeaker to a smartphone’s microphone. Credit: Colourbox Decoding Beethoven’s music style using data science Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. More information: Eichelberger M, Tanner S, Voirol G, Wattenhofer R: Imperceptible Audio Communication. 44th IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), Brighton, 12-17 May 2019, tik-old.ee.ethz.ch/file/8a61c1 … io_communication.pdflast_img read more

Win 4 Weekend Tickets to the BlueDot Festival 2019 in the UK

first_imgDo you love music? Do you love science? Would you like to go to a festival where both are rolled up into a weekend of family fun? Well look no further, as we’re giving away four tickets (two adults plus two teens (11 to 15 years old) for a weekend of camping and festival-going at BlueDot festival, located at Jodrell Bank Observatory, Cheshire, United Kingdom. Kicking off on Thursday, July 18, this event will last through Sunday (July 21) and will be jam-packed with science, art and music in the most creative and immersive fashion. Not only will there be talks from the brightest scientists from around the globe, but there will be a selection of world-famous art on display. The main stage will sit in the foreground of the observatory’s Lovell Telescope, which has been at the forefront of scientific discovery for over half a century. Thursday will begin the long weekend of musical acts, including an opening convert from The Hallé. The kick-off will see music acts such as Hot Chip, Jon Hopkins, Kate Tempest and Ibibio Sound Machine, among many more. Saturday will welcome Kraftwerk 3-D, Jarvis Cocker, 808 State, Sons of Kemet and more. Finally, Sunday will finish with multiple award-winning New Order, John Grant, Gruff Rhys, Anna Calvi, Gogo Penguin and others.Headbutting Tiny Worms Are Really, Really LoudThis rapid strike produces a loud ‘pop’ comparable to those made by snapping shrimps, one of the most intense biological sounds measured at sea.Your Recommended PlaylistVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Why Is It ‘Snowing’ Salt in the Dead Sea?01:53 facebook twitter 发邮件 reddit 链接https://www.livescience.com/65823-win-tickets-bluedot-festival.html?jwsource=cl已复制直播00:0000:3500:35  But it’s not just the music that people travel from around the world to see, and this includes the brilliant scientists and engineers providing brilliantly informative talks about the latest in STEM subjects. Such names include Britain’s first astronaut Helen Sherman, famous science historian James Burke, French-Irish science and history presenter Liz Bonnin and other exciting names in the world of science, including Jim Al-Khalili, Dallas Campbell and the director of Jodrell Bank, Tim O’Brien. In between the music and the science, there are opportunities to visit some exciting stalls with a variety of interesting cuisines; there are comedy shows, stargazing, microbrewery, mixology, family events, a deep-space disco and so much more. *Please note that the ticket isn’t valid until 9 a.m. on July 19. To be in for the chance of winning tickets to an unforgettable weekend of science and music, all you need to do is enter here before the July 10.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GamePlay this for 1 min and see why everyone is addicted!Vikings: Free Online GameUndoTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndoKelley Blue Book2019 Lexus Vehicles Worth Buying for Their Resale ValueKelley Blue BookUndoGundry MD Total Restore SupplementU.S. Cardiologist: It’s Like a Pressure Wash for Your InsidesGundry MD Total Restore SupplementUndoTop 10 Best Meal DeliveryMeal Kit Wars: 10 Tested & Ranked. See Who WonTop 10 Best Meal DeliveryUndoArticles VallyDad Cuts Daughter’s Hair Off For Getting Birthday Highlights, Then Mom Does The UnthinkableArticles VallyUndolast_img read more

Army joins rescue operations in Kodagu

first_imgPublished on SHARE SHARE EMAIL Karnataka Telugu States on alert as Godavari swells; Theni, Madurai also under threat forecast Tourists take in the breathtaking view of the Barachukki andGaganachukki Waterfalls on the Cauvery river at Shivanasamudranear Malavalli, about 130 km from Bengaluru, on Thursday. The fallcame alive following heavy outflow from the KRS and the Kabinireservoirs as rain continues to batter the catchment areas of theCauvery. – K MURALI KUMAR Flood alert in Theni, Madurai; 8,410 people in relief camps The army has joined operations to rescue people stranded in floods and landslides in rain-battered Kodagu district.Several districts of coastal and Malnad regions of the State, such as Dakshina Kannada, Udupi, Chikkmagaluru, Kodagu, and parts of Hassan and Uttara Kannada, have been facing the brunt of incessant rains in the last few days.“Army has joined the rescue operation along with National Disaster Response Force, Fire department, Quick Response Team, among others,” the Chief Minister’s office said in a statement.Chief Secretary Vijay Bhaskar informed Chief Minister Kumaraswamy about the rescue operations in the flood and landslide-hit districts of coastal and Malnad regions, it said.The statement said the Chief Minister was also constantly in touch with the district in-charge ministers who are stationed in their respective districts to monitor the rescue operations. In-charge secretaries are managing the rescue operations.Kumaraswamy had yesterday announced a grant-in-aid of ₹200 crore to the affected districts for relief work. He had also directed the district administrations to estimate the losses and submit a report in a couple of days, following which the State government is expected to approach the Centre for help.Godavari in spateThe Godavari river is in spate in Andhra Pradesh and Telengana with the government machinery put on alert in three districts on Friday following the first flood warning, officials said.As the river carried over 12 lakh cusecs of water in the wake of heavy rains in catchment areas, emergency rescue and relief teams, including that of national and state disaster response forces, have been positioned in East and West Godavari districts of Andhra Pradesh to meet any eventuality.Two villages have been marooned in East Godavari district leading to evacuation of around 100 families as the first flood warning was issued in the state and in Badrachalam in Telangana.Andhra Pradesh Deputy Chief Minister (Home) N China Rajappa appealed to people living along the river’s banks in East and West Godavari districts to be on alert and move to safety when required.The water flow at Sir Arthur Cotton Barrage at Dowaleswaram in East Godavari District was over 12.1 lakh cusecs, prompting officials to issue the first warning. The second warning will be issued when the discharge crosses 13 lakh cusecs, the State Disaster Management Authority said.In Telengana, water level in the Godavari river in the temple town of Bhadrachalam was close to the second warning mark of 48 feet today, officials said in Hyderabad. Bhadradri-Kothagudem District Collector Rajiv Gandhi Hanumanthu has directed the official machinery to be on alert.A flood control room had been opened and further measures, including setting up relief camps for accommodating people from low-lying areas, would be taken based on further rise in the water level, they said.East Godavari district Collector Kartikeya Misra told PTI over phone from Kakinada that the situation was under control right now and they were closely monitoring the situation.“Some 100 families have been affected in the two villages under Devipatnam mandal that were marooned and we have moved them to safety. Revenue, police, the NDRF and SDRF teams have been deployed in Rajamahendravaram and we are prepared to tackle any eventuality,” he said.Construction work on the Polavaram dam had been stopped in view of the flood in the Godavari. Water level at Polavaram was around 42 feet this afternoon.Flood alert in TNA flood alert has been sounded in Theni and Madurai districts of Tamil Nadu and people living along the banks of the Cauvery and the Bhavani advised to move to safer places, even as over two lakh cusecs of water was discharged from three dams, including Mettur.As many as 8,410 people have been sheltered in relief camps in Tamil Nadu in view of the heavy inflow from Karnataka reservoirs and combined discharge of over 2.30 lakh cusecs from Mettur, Bhavani Sagar and Amaravathi dams, officials said today.With over 2.07 lakh cusecs being released from the KRS reservoir and Kabini in Karnataka, inflow into the Mettur dam stood at 1.70 lakh cusecs this morning.The water level in the dam stood at 120.24 feet against the full level of 120 feet, officials said, adding, 1.70 lakh cusecs was being discharged.Following heavy inflow and discharge from the Periyar and Vaigai dams, a flood alert has been sounded now in Theni and Madurai districts, Revenue Minister R B Udaya Kumar said.With this, the alert has been issued in 13 districts. SHARE RELATED Tamil Nadu Andhra Pradesh Cauvery in spate; inundates low-lying areas, swamps crops in TN August 17, 2018 flood COMMENT COMMENTSlast_img read more

Spontaneous shutdown in Kashmir over Article 35A rumours

first_img SHARE SHARE EMAIL RELATED COMMENT Strike over Article 35A cripples life for second day SHARE Spontaneous shutdown was observed at several places in Kashmir after clashes broke out between youths and security forces following rumours about scrapping of Article 35A, a police official said. Article 35A, which accords special rights and privileges to the citizens of Jammu and Kashmir, is facing a legal challenge in the Supreme Court. “Spontaneous shutdown is being observed in many places in Srinagar, the summer capital of Jammu and Kashmir, and Anantnag district in south Kashmir,” the official said. He said announcements were made on loudspeakers that Article 35A has been scrapped and people were asked to observe a strike and come out to protest. “Shops and other business establishments, which had opened this morning, downed shutters after rumours of Article 35A being scrapped spread like wild fire and were circulated on social media, the official said. Stone-pelters clashed with security personnel in Anantnag and in the Safakadal area here in the wake of the rumours, he said. The official said security forces are on the job to control the situation. In a statement, police appealed to people to maintain calm and not pay heed to rumours. “Some sections of media circulated news regarding Article 35A. The news is refuted as baseless. People are requested to maintain calm and not to pay heed to rumour. The main hearing is on August 31, the statement said. Article 35A was incorporated in the Constitution by a 1954 Presidential Order. August 27, 2018center_img Jammu and Kashmir Supreme Court adjourns hearing on pleas challenging Article 35 A A file photo of a bandh   –  Rohit Jain Paras COMMENTS Published onlast_img read more

CII welcomes Kerala reforms to improve ease of doing business

first_imgSHARE SHARE EMAIL February 14, 2019 COMMENTS Kerala Published on SHARE CII COMMENT Confederation of Indian Industry (CII) welcomes the series of reform measures taken up by the Kerala Chief Minister Pinarayi Vijayan in improving the ease of doing business in the State.R Dinesh, Chairman, CII Southern Region, in a statement said “CII is working closely with the State Government in promoting ease of doing business and help the state achieve a quantum jump on ease of doing business rankings”.Dinesh said that the initiatives such as; K-SWIFT (Kerala Single-window Interface for Fast, Transparent Clearances), Common Application Form (CAF) and Intelligent Building Planning Management Software (IBPMS) would fast track approvals for setting up new businesses and boost industrial activity.CII also complimented Government for releasing the ‘Invest Kerala Guide’, a compendium of administrative and policy reforms which would act as a ready reckoner for potential investors. CII will continue to work closely with the Government towards achieving a holistic socio-economic growth in the State.last_img read more